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By G. M. J. Beijersbergen van Henegouwen (auth.), Philip L. Chambers, Claire M. Chambers, Guy Dirheimer (eds.)

ISBN-10: 3540185127

ISBN-13: 9783540185123

ISBN-10: 3642731139

ISBN-13: 9783642731136

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Extra resources for The Target Organ and the Toxic Process: Proceedings of the European Society of Toxicology Meeting Held in Strasbourg, September 17–19, 1987

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Acknowledgments. We wish to thank L. Tosi and M. Jones for their skilful technical help, and L. Mascaro for the typewriting. References Chalmers RJG, Skrinivas V, Benett DH, Muston HL (1982) The incidence of photosensitivity and pigmentation induced by the anti-arrhythmic drug amiodarone. Br J Dermatoll 07 [Suppl 22]:32-33 Photosensitizing Potential in Animals 25 Daymond TJ, Diffey BL (1983) Narrow band photosensitivity in patients taking benoxaprofen. Br J Clin Pharmacol 15:139 Ferguson J, Addo HA, McGill PE, Woodcook KR, Johnson BE, Frain BW (1982) A study of benoxaprofen induced photosensitivity.

It was thus confirmed that BXP induces photo toxic and photoallergic reactions in the animal like in man. These results PHOTOALLERGY PHOTOTOXICITY 4 (jj a: 3 ~ 0 ... ~ I > fiii Z w 2 f- ~ Z 0 f= / « w a: 0 (50 mg/kg) I , olio 2 3 2 I I I 0)-t1 I I () (INDUCTION DOSE: 50 mg/kg) CRE 8182 . 5 I j' 3 0 I 123456 JtJ 1 2 3 4 5 6 N° GUINEA PIG , ' CRE 8182 ~,. olio 6 7 , , , 8 CI Na 9960 DAYS 25 mg/kg BENOXAPROFEN 25 mg/kg CHALLENGE DOSE Fig. 3. Phototoxicity and photoallergy of orally administered anti-inflammatory/analgesic drugs (UVA spectrum) 22 J.

Mutat Res 174:241~246 Boyer V, Moustacchi E, Sage E (1988) Sequence specificity in photoreaction of various psoralen derivatives with DNA: role in biological activity. Biochemistry 27:3011~3018 Brigdes BA, Stannard M (1982) A new pathway for repair of cross-linkable 8-methoxypsoralen monoadducts in uvr strain of Escherichia coli. Mutat Res 92:9~14 Bridges BA, Von Wirght A (1981) Influence of mutations at the rep gene on survival of E. coli following UV irradiation or 8-methoxypsoralen photosensitization.

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The Target Organ and the Toxic Process: Proceedings of the European Society of Toxicology Meeting Held in Strasbourg, September 17–19, 1987 by G. M. J. Beijersbergen van Henegouwen (auth.), Philip L. Chambers, Claire M. Chambers, Guy Dirheimer (eds.)


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