Read e-book online Stem Cell and Gene-Based Therapy: Frontiers in Regenerative PDF

By Alexander Battler MD, FACC, FESC, Jonathan Leor MD, FACC, FESC (auth.)

ISBN-10: 1846281423

ISBN-13: 9781846281426

ISBN-10: 1852339799

ISBN-13: 9781852339791

Regenerative drugs - stem mobile and gene-based treatment - presents a brand new medical strategy for restoring functionality of broken organs and tissues. there was amazing development in experimental concepts for tissue regeneration, fairly in mobilephone transplantation and stem telephone study. those have resulted in power therapies for lots of differently deadly stipulations, together with end-stage organ failure. mobilephone remedy and tissue engineering of plausible grafts may accordingly supply potential new suggestions to the intense difficulties of organ donor shortage.

Stem mobilephone and Gene-Based treatment: Frontiers in Regenerative Medicine is written by means of the major figures within the box of stem cells, gene treatment and tissue engineering and covers the main methods to regenerative drugs, making sure that ideas learnt in a single self-discipline are disseminated throughout different parts of medication. this enables practitioners to realize wisdom not just of ways regenerative medication applies to their very own self-discipline without delay but in addition the way it will gain their sufferers within the future years. for that reason, the multidisciplinary nature of the booklet appeals to scholars, scientists and clinicians from a large spectrum of disciplines, together with cardiology, pulmonology, neurology, ophthalmology, orthopedics, and dermatology.

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Extra info for Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine

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In the following text, we will discuss the pathophysiologic background of ischemic heart failure and the rationale for the use of adult stem cells to regenerate ischemic myocardium. We will further highlight information on contractile muscle-derived regenerative cells as well as adult stem cells from hematopoietic tissue to build a basis for a critical discussion of the ongoing clinical trials. Ischemic Heart Disease Despite a better understanding of its etiology, the prevalence of ischemic heart disease remains exceedingly high in industrialized countries, and is on the rise in developing countries.

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29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. Heart Lin Y, Weisdorf D, Solovey A, Hebbel RP. Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 2000;105:71–77. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964–967. Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel RP. Circulating activated endothelial cells in sickle cell anemia. N Engl J Med 1997;337:1584–1590. Kocher AA, Schuster MD, Szabolcs MJ, et al.

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Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine by Alexander Battler MD, FACC, FESC, Jonathan Leor MD, FACC, FESC (auth.)

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