By A. Dold, B. Eckmann
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Extra info for Seminaire Pierre Lelong (Analyse) Annee 1970
Eur. J. Clm. Phurmucol 14, 341-350 Pang S. and Rowland M. (1977) Hepatic clearance of drugs. Theoretical conslderatlons of a “well-stirred” model and a “parallel-tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity in hepatic drug clearance. J, Phurmucokm. Blopharm 5, 625-653 Piafsky K. M. and Borga 0. (1977) Plasma protein binding of basic drugs. II. Importance of al-acid glycoprotein for mtermdlvldual vanatlon. Clm. Pharmacol. Ther.
Scz 66, 447465 Veldstra H. (1956) Synergism and potenhation. Pharmacol. Rev. 8, 339387 Wagner J. G. (1985) Commentary: Relationships among the venous equilibration (“well-stirred”) model, the sinusoidal perfusion (“parallel-tube”) model, and a specific two-compartment open model. Drug Metab. Dlspos. 13, 119-120. Wagner J. , Szpuner G. , and Ferry J. J. (1984) Commentary: Exact mathematical equivalence of the venous equilibration (“wellstirred”) model, the smusoidal perfusion (“parallel-tube”) model, and a specific two-compartment open model.
However, our understanding of tissue binding is weak. The following apparently occur: (1) adsorption of lipophilic drugs to surfaces of membranes, such as the outer surface of red Protein Binding of Psychotropic Drugs 27 cells and linings of blood vessels; (2) penetration of membranes to give significant drug concentrations inside cells; (3) adsorption of drugs to constituents of cells; (4) solution of drugs in fatty areas. It should be recognized that some of the intracellular adsorption is to specific sites within cells; and some is to nonspecific sites.
Seminaire Pierre Lelong (Analyse) Annee 1970 by A. Dold, B. Eckmann