By Lazaros C. Triarhou (auth.)
This publication is the fruits of fifteen years of analysis at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterised by means of genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the single to be had laboratory version with a prolonged sickness that mimics Parkinson's ailment. Structural and useful facets of intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical elements of donor mobile survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor similar molecules, degrees of striatal amino acid receptors, and behavioural results of unilateral and bilateral neuronal transplantations.
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Extra resources for Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease
Nigral Dopaminergic Dendrites Heterozygous weaver mice have normal DA neuron numbers in all three areas at 20 and 90 days of age. 34,35 Using TH immunocytochemistry (Fig. 7), a subcellular site was found to be defective in the substantia nigra of mice both heterozygous and BIOLOGY AND PATHOLOGY OF THE WEAVER MUTANT MOUSE 23 Figure 8. Immunocytochemistry with a monoclonal antibody against microtubule-associated protein 2 (MAP2), a molecule selectively localized in dendrites, to show dendritic extension into the substantia nigra pars reticulata in wild-type (a), heterozygous weaver (b) and homozygous weaver midbrain (c).
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Reeves RH, Crowley MR, Lorenzon N et al. The mouse neurological mutant Weaver maps within the region of chromosome 16 that is homologous to human chromosome 21. Genomics 1989; 5:522-526. 25. Mjaatvedt AE, Citron MP, Reeves RH. High-resolution mapping of DI6Ltd-l. Gart, Gas-4, Cbr. Pcp-4, and Erg on distal mouse chromosome 16. Genomics 1993; 17:382-386. 26. Patil N, Cox DR, Bhat D et a!. A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation.
Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease by Lazaros C. Triarhou (auth.)