Download PDF by Erik De Clercq (auth.), Erik D. A. De Clercq, Anne-Mieke I.: Combination Therapy of AIDS

By Erik De Clercq (auth.), Erik D. A. De Clercq, Anne-Mieke I. Vandamme (eds.)

ISBN-10: 3034878699

ISBN-13: 9783034878692

ISBN-10: 3034896042

ISBN-13: 9783034896047

HIV an infection has been a better problem to present medication than the other viral sickness ofmodem instances. HIV ends up in a continual an infection and the virus has an enormous genetic flexibility lower than selective strain. in the course of its copy­ tive cycle in sufferers, HIV accumulates mutations at this kind of excessive expense that the selective strain inflicted at the immune method, or generated through antiviral medicinal drugs swiftly triggers the looks of break out mutants. at present on hand medicines, whilst used singly, will not be able to suppressing virus replication in sufferers to one of these point that the new release of mutations, from which a version immune to immune assault or antiviral medicinal drugs may be chosen, is avoided. this can be the most it's because mixture treatment, often of 3 medicinal drugs, has develop into the normal approach for the remedy ofAIDS. it really is visible that virus eradication won't quite simply be feasible, in order that medicines need to be taken for a protracted time or perhaps lifelong with the intention to continue the viral load as little as attainable. no matter if the at the moment used drug combos could be in a position to keep watch over virus replication in a specific sufferer for this kind of professional­ longed time period relies on many elements, such a lot of that are addressed within the various chapters of this ebook. the purpose of antiviral drug blend treatment for AIDS is finally to revive complete functionality of the immune system.

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AIDS Clinical Trials Group Study 175 Virology Study Team. N Eng! 1 Med 335: 1091-1098 16 Lathey JL, Hughes MD, Fiscus SA, Pi T, Jackson JB, Rasheed S, Elbeik T, Reichman R, Japour A, D' Aquila RT et al. (1998) Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type I-infected patients with 200-500 CD4 cells/mm 3 (ACTG 175). AIDS Clinical Trials Group Protocol 175 Team. 1 Infect Dis 177: 617-624 17 Delta Coordinating Committee (1996) Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIVinfected individuals.

J Med 323: 1009-1014 Fischl MA, Richman DD, Hansen N, Collier AC, Carey JT, Para MF, Hardy WD, Dolin R, Powderly WG, Allan JD et al. (1990) The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. A double-blind, placebo-controlled trial. The AIDS Clinical Trials Group. Ann Intern Med 112: 727-737 Volberding PA, Lagakos SW, Koch MA, Pettinelli C, Myers MW, Booth DK, Balfour HH Jr, Reichman RC, Bartlett JA, Hirsch MS et al.

1997) Azodicarbonamide inhibits HIV-l replication by targeting the nucleocapsid. Nature Medicine 3: 341-345 Goebel F-D, Hemmer R, Schmit J-C, Bogner JR, De Clercq E, Witvrouw M, Pannecouque C, Valeyev R, Vandevelde M, Margery H et al. (2001) Phase IIII dose escalation and randomized withdrawal study with add-on azodicarbo-namide in patients failing on current antiretroviral therapy. AIDS 15: 33-45 De Clercq E (1995) Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections.

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Combination Therapy of AIDS by Erik De Clercq (auth.), Erik D. A. De Clercq, Anne-Mieke I. Vandamme (eds.)

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