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Laboratory findings in DIC include thrombocytopenia, hypofibrinogenemia, increased FDPs (or D-dimer), and prolonged TT and PTT. The treatment of DIC initially involves the treatment of the underlying cause. Conscientious management of hemodynamic and oxygenation support is critical. Correction of coagulopathy with platelet transfusions, FFP, and cryoprecipitate should be undertaken for bleeding complications. v. without a bolus) and titrated upward as tolerated, but the benefit remains unproven.
A check of the identity of the donor unit and recipient is required because most ABO reactions today are the result of clerical error. A repeat of the cross-match should be performed with samples of the recipient's serum and the remaining donor unit. Plasma hemoglobin should be determined as well as serum bilirubin and blood coagulation parameters. Treatment includes maintenance of intravascular volume, hemodynamic support as needed, and preservation of renal function. Urine output should be maintained at greater than 100 mL per hour using volume resuscitation, diuretics, and mannitol, if needed.
It also improves blood flow by volume expansion and reduces factor VIII activity. v. v. during the postoperative period) can be used for prevention of DVT and PE. v. v. starting on the day of surgery for 4 days) ( J Vasc Surg 1:765, 1984). Complications of dextran infusion include bleeding, volume overload, and allergic or anaphylactoid reactions. Allergic reactions are prevented or decreased by preinfusion of short-chain dextrans. Of the two types of dextran that are available, dextran 40 leads to less volume overload and bleeding complications than does dextran 70.
Chirurgia Washington Manual Of Surgery