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By I. Leusen, J. Weyne (auth.), Professor Dr. Marianne E. Schläfke, Dr. Wolf R. See M.A., Professor Dr. Hans-Peter Koepchen (eds.)

ISBN-10: 3642686575

ISBN-13: 9783642686573

ISBN-10: 3642686591

ISBN-13: 9783642686597

This quantity comprises the papers provided on the symposion on valuable Neurone surroundings and the regulate structures of respiring and movement held at Bochum, October 5-7,1981 in honour of Prof. Dr. Dr. h.c. Hans H. Loeschcke, who retired in March 1981. His discovery of ventral medullary substrates forming a vital force for the ventilatory in addition to for circulatory keep an eye on platforms, and the elaboration of this idea over the past 25 years have profoundly inspired the suggestions during this box. In an age of continuing specializa­ tion on partial mechanisms, his strategy has consistently emphasised the integrative points of the keep watch over platforms, in particular the function of the breathing keep watch over process for the ionic homeostasis of the mind and the shut interrelation among neuronal breathing and cardiovascular keep an eye on. This common goal implies the combo of physico­ chemical and neurophysiological ways in addition to the research of peripheral functionality of respiratory and move, issues that are often dealt with individually based on different methods.

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Luttmann and K. 8 54 I I I I I CF = 1 ~ : ; -20 7 .. 40 738 5 Iung passage 15 25 .. t[sl Fig. S. Calculated pC0 2 and pH time courses in blood during and after lung transit. 3 kPa) instantaneously when blood reaches the lung. During lung passage (T = 700 ms) different catalyzing factors CF are acting in the plasma. After leaving the lung CF is assumed to be l. In the left part of the diagram the time function in the first seconds, in the right part the later state of reaction after blood has left the pulmonary capillary is shown reaction is catalyzed by lung carbonic anhydrase, a fast increase of the pHp is obtained during lung transit time.

For reasons of respiration physiology it is important to know whether or not the blood acid base quantities have reached their final value when leaving the lung or passing the peripheral chemoreceptors or central chemosensitive structures, because the magnitude of ventilation and consequently the acid base status of the whole body is mainly determined by the actual acid base values at these structures. Since the end of the last century the mechanism of gas transport by the blood was well investigated by a great number of scientists, and the knowledge of the chemical reactions and transport events that occur in blood after gas exchange was summarized by Roughton in 1964.

After adding CO 2 the pC0 2 increases abruptly. Then the physically dissolved CO 2 is transformed into bound CO 2 resulting in a decrease of the pC0 2 . During this process the H ion concentration in the plasma increases whereas the chloride concentration decreases depending on the bicarbonate-chloride exchange. The electrical resistance, indicating the actual cell volume increases due to an osmotically induced water shift into the cells. , i !!!! I I Torri IkPol 60 8 40 20 6 45 n = 23 I I I I I ----i 0 12 8 16 .

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Central Neurone Environment and the Control Systems of Breathing and Circulation by I. Leusen, J. Weyne (auth.), Professor Dr. Marianne E. Schläfke, Dr. Wolf R. See M.A., Professor Dr. Hans-Peter Koepchen (eds.)


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