Anti-obesity drug discovery and development Volume 1 by Atta-ur- Rahman; M Iqbal Choudhary PDF

By Atta-ur- Rahman; M Iqbal Choudhary

ISBN-10: 1608051633

ISBN-13: 9781608051632

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Extra info for Anti-obesity drug discovery and development Volume 1

Sample text

It iis a “neurosstabilizer” th hat attenuatees the excitaability of braain neuronaal pathways.

Monoamine neurotransmitters reduce appetite by decreasing neuropeptide Y, and increasing pro-opiomelanocortin [273] and anorexigenic peptide, termed ‘cocaine and amphetamine-regulated transcript’ (CART), which is located in the hypothalamus, [274]. Amphetamine action mechanisms on central nervous system (CNS) include an increase in dopamine, norepinephrine and serotonin activity. Amphetamines are sympathomimetic agents which act upon obesity by increasing energy expenditure through diverse mechanisms, such as increasing thermogenesis [275], although this has been mainly studied in animals, while only a handful of clinical trials have shown that effects in humans [276-278].

Improved physical conditioning has been also associated with reduced arterial stiffness [259]. Regular aerobic exercise, and even modest physical activity, has shown to prevent the age-related decline in vascular endothelial function [260-262], suggesting an important mechanism by which regular aerobic exercise reduces the risk for cardiovascular disease. Physical activity has a beneficial impact on endothelial progenitor cells (EPC), which play an important role in repairing endothelial injury.

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Anti-obesity drug discovery and development Volume 1 by Atta-ur- Rahman; M Iqbal Choudhary


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