By Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann, Brian L. Samuels (eds.)
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Extra info for Annals of Oncology: Official Journal of the European Society for Medical Oncology
45 sll-2R sll-2R (Uiml) 11L-2R f Ulml Ulml 13000 } ' 10000 2000 5000 2000 1000 1000 1000 n = SO lA IIA 118 lilA n = 10 n = 17 n= 7 n = 15 1118 n = 14 IVA n =4 IV8 n Fig. 1. siL-2R levels in the pretreatment sera of 82 newly diagnosed patients with Hodgkin's lymphoma. Correlation with other parameters The correlation of pretreatment siL-2R with other clinical and laboratory parameters is shown in Table 2. Levels of siL-2R were strongly correlated with B-symptoms. Using Spearman's correlation coefficient, there was also a correlation with erythrocyte sedimentation rate, LDH, and alkaline phosphatase, while the correlation with albumin and leukocyte and lymphocyte counts was weak.
Micklem K, Cordell J, Rigney E, Simmons D, Pulford K, Stross P, Mason DY. A macrophage-assoc iated antigen defined by five mAb. : Leucocyte Typing IV, Oxford University Press, Oxford, 1990; pp. 843-846. Backe E, Schwarting R, Gerdes J, Ennen J, Stein H. BerMAC3: A new monoclonal antibody that defines a monocyte/ macrophage activation antigen (submitted). Gadd S. Report on unclustered antibodies. : Leucocyte Typing IV. Oxford University Press, Oxford, 1990; pp. 846-850. Correspondence to: Prof. Dr.
23] and our group , the EBV genome indeed proved to be monoclonal. Therefore, it follows that the tumor cells harboring EBV must be monoclonal as well and that the virus entered the tumor cells prior to clonal expansion. Since the sensitivity of direct filter hybridization techniques is limited, and since the EBV-harboring HRS cells constitute only a small percentage of the total number of cells in HD-afflicted tissue, it is conceivable that EBV escaped detection in many cases. We therefore extended our investigations to enzymatic DNA amplification by polymerase chain reaction (PCR) .
Annals of Oncology: Official Journal of the European Society for Medical Oncology by Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann, Brian L. Samuels (eds.)