By Dr. Adam Schneeweiss, Dr. Marija Weiss (auth.)
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5 h after the first dose ofISDN but it did prolong this period in patients studied, at the same interval, during chronic treatment with ISDN. This finding shows some attenuation of the effect ofISDN, but no cross-tolerance to nitroglycerin. 5. Hemodynamic Effects of Bolus Nitroglycerin Compared with Those of Continuous Infusion When administered intravenously, nitroglycerin is usually given in the form of continuous infusion. Most hemodynamic studies have been performed with this mode of administration.
Acute Myocardial Infarction In previous chapters it has been shown that nitrates are used to treat various preinfarction ischemic conditions as well as postinfarction complications, such as acute heart failure, mechanical complication and postinfarction angina. Nitrates may also be used for acute myocardial infarction per se. Moreover several early intervention studies revealed beneficial effects of other anti-ischemic agents such as beta-adrenoreceptor blockers in acute myocardial infarction. Therefore it is interesting to review the facts and hypotheses on the use of nitrates in these conditions.
This reduction was fully achieved also during chronic therapy. 3 L min-1 m-2• This hemodynamic improvement was associated with sustained improvement in exercise capacity and in ST -segment depression. Long-Term Use of Nitrates in Angina Pectoris 37 Recently Distante et al  used a different approach to study the possibility of tolerance to long-term nitrate therapy. They evaluated the hemodynamic response to an acute infusion oflSDN, 1 mg/min, up to a maximal dose oflO mg, in eight patients with vasospastic angina chronically treated with high doses of transdermal ISDN, 150-300 mg daily.
Advances in Nitrate Therapy by Dr. Adam Schneeweiss, Dr. Marija Weiss (auth.)